The present study was undertaken to determine the effect of estrogen and progesterone on the concentration of estradiol receptor in uterine tissue at the early pregnant rats. _
The results obtained are as follows :
1) The uterus wet weights of ovariectomized rats were decreased, while the concentration of estradiol receptor ( E2 R ) was increased, it seems to be well correlated with the low level of estrogen.
2 ) In the rats treated with estradiol, at 24 hours after treatment, the concentration of E2 R was higher than control - vehicle treatment groups.
3 ) In the rats treated with estrogen and progesterone, the concentration of E2R decreased, whereas estrogen primed rats treated with progesterone, the concentration of E2 R increased relatively.
It is, therefore, concluded that the concentration of cytosol E2 R seems to be correlated with the peripheral estrogen and progesterone levels, and then cytosol E2 R transfers into nuclear estradiol receptor to stimulate mRNA transcription for the development of uterine tissue.
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